Author/Authors :
Pourmoghaddas, Zahra Child Growth and Development Research Center - Isfahan University of Medical Sciences, Isfahan - Pediatric Infections Research Center - Research Institute for Children Health - Shahid Beheshti University of Medical Sciences, Tehran , Ansari, Narges Child Growth and Development Research Center - Isfahan University of Medical Sciences, Isfahan , Dehghan, Bahar Child Growth and Development Research Center - Isfahan University of Medical Sciences, Isfahan , Famori, Fatemeh Child Growth and Development Research Center - Isfahan University of Medical Sciences, Isfahan , Saneian, Hosein Child Growth and Development Research Center - Isfahan University of Medical Sciences, Isfahan
Abstract :
Objectives: The aim of this study was to evaluate endothelial dysfunction in pediatric patients with Helicobacter pylori infection.
Methods: In a cross sectional study, 50 children between six and twelve years old were evaluated for Helicobacter pylori infection by
a histopathologic specimen. C-reactive protein (CRP) and Interleukin -12 of all subjects was checked. Endothelial dysfunction was
evaluated by echocardiography of brachial artery and through measuring flow mediated dilatation (FMD).
Results: Meanof FMDlevel was significantly higher in children with H. pylori infection (P value: 0.04). Interlukin-12 (IL-12) was higher
in children with H. pylori infection (P value: 0.04). Linear regression showed a positive association of Helicobacter pylori infection and
endothelial dysfunction (beta = 0.3, P value = 0.08).
Conclusions: Children with Helicobacter pylori infection have more endothelial dysfunction independent of IL-12.
