Title of article
Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem FerulateAcrylamide/Methyl Methacrylate Composite
Author/Authors
Zuo ، Kai - Guilin University of Technology , Qian ، Jingxia - Guilin University of Technology , Gong ، Jun - Guilin University of Technology , Zhang ، Jun - Guilin University of Technology , Li ، Heping - Guilin University of Technology , Zhou ، Guoyong - Guizhou Minzu University
Pages
10
From page
107
To page
116
Abstract
BXFL (bagasse xylem ferulate)-g-AM (acrylamide)/MAA (methyl methacrylate) was synthesized based on bagasse xylan(BX)-g-AM/MAA in 1-Butyl-3-methylimidazolium chloride ([Bmim] Cl) ion solution with Ferulic Acid (FL) as esterification agent. The various factors that were investigated influenced carboxylic acid ester substitution degree (DSC) of BXFL-g-AM/MAA. The structures of BXFL-g-AM/MAA were confirmed by IR, SEM and ^1H NMR analysis. The cytotoxicity of BXFL-g-AM/MAA was investigated against twelve kinds of protein through Surflex-Dock Mode of Sybyl-X 2.0 software, and on three kinds of human cancer cells line and the human normal cells line were detected by MTT assay. It was shown that the maximum DSC was 1.09 in ion solution, which was superior to DSC of conventional method in organic solvent. The results of MTT assay were consistent with docking results. BXFL-g-AM/MAA exhibited relative high cytotoxicity against human gastric cancer cells (MGC-803) line.
Keywords
Bagasse Xylem ferulate , acrylamide , methyl methacrylate , Synthesis , Characterization , Cytotoxicity , Molecular docking
Journal title
Iranian Journal of Chemistry and Chemical Engineering(IJCCE)
Serial Year
2019
Journal title
Iranian Journal of Chemistry and Chemical Engineering(IJCCE)
Record number
2470327
Link To Document