Poly(Pyrrole) Conducting Polymer Solid-State Sensor for Potentiometric Determination of Fluoxetine

An electrochemical potentiometric sensor was introduced for Fluoxetine (FLX) analysis in pharmaceutical formulations using conducting polymer coated on a solid-state contact. FLX is one of the antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. For this purpose, pyrrole was electrochemically polymerized on the surface of a solid contact made of graphite to form a thin layer of poly(pyrrole) (PPy). After this step, a thin layer of another polymeric composite composed of poly(vinyl chloride), dibutyl phthalate and ion-pair compound of FLX and phenyl borate was covered on the treated surface. The modified graphite rod was finally used as a working electrode in a potentiometric cell assembly. Linear concentration range of 1.0×10−6 to 1.0×10−3 mol L-1, lower detection limit of 6.3×10−7 mol L-1, 8s response time, and two months lifetime were the characterizations of the proposed sensor. Finally, FLX content of some pharmaceutical samples were analyzed by the prepared sensor accurately and precisely.