Author/Authors :
Madhuri, Chougoni Department of Chemistry - Sri Venkateswara University, Tirupati, India , Kiranmai, Sundupalle Department of Chemistry - Sri Venkateswara University, Tirupati, India , Kumara Swamy, Bahaddurghatta E Department of P.G Studies and Research in Industrial Chemistry - Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka , India , Padmavati, Vavilla Department of Physics - S. V. Arts College, Tirupati , Yugandhar Reddy, Patil Department of Zoology - The Adoni Arts and Science College, Adoni, Kurnool , Madhavi, Gajulapalli Department of Chemistry - Sri Venkateswara University, Tirupati, India
Abstract :
In the present study, a highly sensitive electrochemical sensor was developed for the trace analysis of paracetamol using voltammetric techniques. The electrochemical redox behavior of paracetamol was investigated by Fe3O4@SiO2 on surface of GCE using drop casting technique. It showed a supreme electrocatalytic activity at pH 5.5 in 0.1 M PBS. The surface morphology of Fe3O4@SiO2 was studied using SEM and FT-IR. The effect of sweep rate, pH and concentration of paracetamol were investigated. The oxidative peak current of paracetamol was increased linearly while increasing its concentration from 0.8-24 nM and the LOD and LOQ were found to be as low as 4.88 nM (S/N=3) and 19 nM respectively, which is found to be much sensitive than many methods reported in the literature. DPV technique was used for the simultaneous detection of paracetamol in presence of etilefrine and dopamine.
Keywords :
Fe3O4@SiO2 nanocomposite , Electrochemical sensors , Dopamine hydrochloride , Etilefrine hydrochloride , Paracetamol
