Title of article :
Apoptosis Induced by Viola odorata Extract in Human Glioblastoma Multiforme
Author/Authors :
sourtiji, hossein Functional Neurosurgery Research Center - Shahid Beheshti University of Medical Sciences , hosseini, ali International Campus - Tehran University of Medical Sciences , rassafiani, mehdi Department of Toxicology and Pharmacology - Faculty of Pharmacology - Tehran University of Medical Sciences , kohan, amir Department of Clinical Persian Pharmacy - School of Persian and Complementary Medicine - Mashhad University of Medical Sciences , noroozi, mehdi Department of Neuroscience - School of Advanced Technologies in Medicine - Tehran University of Medical Sciences , motlagh, mohammad esmaeil Brain and Spinal Cord Injury Research Center - Neuroscience Institute - Tehran University of Medical Sciences
Abstract :
Plant extracts contain useful components that could be considered in pharmacotherapy. Due to containing anticancer components such as phenol, cyclotide, and anthocyanins, Viola odorata (sweet violet) is one of the most important components used in can-cer therapy. The current study aimed at examining antitumor activity and related mechanisms to V. odorata on primary culture of human glioblastoma multiforme (GBM). It was observed that survival rate of the obtained astrocytes from human GBM tumor decreased with V. odorata hydroalcoholic extract (10 - 500 µg/mL) in a dose- and time-dependent manner and DNA fragmentation happened in concentrations above 100 µg/mL of this extract. Further observations revealed that induced apoptosis activates mito-chondrial death pathway, release cytochorome C, and activates caspase-3. The current study findings revealed the e ect mechanism of V. odorata extract and suggested its potential application in cancer therapy.
Keywords :
Astrocyte , Apoptosis , Cell Survival , Glioblastoma Multiforme , Viola odorata
Journal title :
Astroparticle Physics
