Title of article
Salivary levels of interleukin‑8 in oral lichen planus and diabetic patients: A biochemical study
Author/Authors
Tavangar, Atefeh Department of Oral and Maxillofacial Medicine - School of Dentistry - Isfahan University of Medical Sciences, Isfahan , Ghalayani, Parichehr Department of Oral and Maxillofacial Medicine - School of Dentistry - Isfahan University of Medical Sciences, Isfahan , Abbasi Boroujeni, Mahsa Department of Prosthodontics - School of Dentistry - Shahrekord University of Medical Sciences, Shahrekord , Ghoreishian, Fereshteh Sadat School of Dentistry - Isfahan University of Medical Sciences, Isfahan
Pages
6
From page
209
To page
214
Abstract
Background: This study aimed to assess the salivary levels of interleukin‑8 (IL‑8) in oral lichen
planus (OLP) and diabetes mellitus (DM) patients, and OLP + DM patients in comparison with
healthy individuals.
Materials and Methods: This descriptive cross‑sectional study was conducted on 75 patients
(30 with OLP, 5 with both OLP and DM, 20 with DM and 20 healthy controls). The salivary levels
of IL‑8 and fasting blood sugar and 2‑h postprandial blood glucose levels were measured in all the
subjects. Data were analyzed with one‑way ANOVA and post hoc least significant difference tests.
Results: The mean salivary level of IL‑8 was the highest in OLP + DM patients, followed by DM,
OLP and control groups, respectively. Pair‑wise comparisons of the groups revealed significant
differences in the salivary levels of IL‑8 between OLP and control, DM and control, also OLP + DM
patients and control (P < 0.05).
Conclusion: The increasing salivary level of IL‑8 in the control, OLP, DM, OLP + DM groups,
respectively, indicates the role of this inflammatory cytokine in the pathogenesis of OLP and diabetes.
Keywords
Diabetes mellitus , interleukin‑8 , lichen planus , saliva
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2471047
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