One-Pot Synthesis of 2-amino-4H-chromenes using L-Proline as a Reusable Catalyst

A new and efficient synthesis of2-amino-chromenes is achieved by one pot three-component reaction of aldehydes, malononitrile, and resorcinol using L-proline as a reusable catalyst. The key advantages of the present process are the use of a bioorganic and reusable catalyst, high yields of products, using green solvent and short reaction times from the principles of green chemistry point of view. L-proline can be reused five consecutive times without a noticeable loss in activity.