Systematic analysis of components and contents in Houttuynia cordata Thunb

Objective:This study aims to provide the material basis for the molecular mechanism of Yuxingcao (Houttuynia cordata Thunb, HCT) through the method of evidencebased study to summarize the natural constituents isolated from HCT. Methods:We searched CNKI, Wanfang, VIP, Pubmed and relevant conference compilations. The keywords were Yuxingcao or Houttuynia cordata Thunb and components or ingredients or constituent or volatile oil or flavonoids or terpene or content , both in Chinese and English. According to the inclusion and exclusion criteria, the reported compositions and contents have been summarized, and SPSS software was used to draw the boxplot of contents. Results:A total of 603 natural compounds in 11 categories were obtained from pooled articles. In the diverse components, the number of aliphatic compounds (n=259) and terpenoids (n=158) are more than those of flavonoids (n=26), alkaloids (n=42) and aromatics (n=42). While, in the part of volatile oils of HCT, the largest components are aliphatic compounds (mainly distributed on the ground) and terpenoids (mainly distributed in the underground). Although, methyl nnonylketone is distributed in the whole herb plant, a large proportion is present in the underground parts. As for non-volatiles, the flavonoid content (mainly distributed on the ground) was the highest, among which quercetin and its glycosyl derivatives were the prominent. Conclusion:The results of this study provide a more comprehensive material basis for the further study of HCT. It is also helpful to explain the mechanisms of anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer effects from the molecular target and molecular network levels.