Author/Authors :
Pourdast, Alieh Department of Infectious and Tropical Diseases - Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High-Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Sanaei, Maryam Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Jafari, Sirous Department of Infectious and Tropical Diseases - Faculty of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Mohammadi, Mostafa Department of Anesthesiology and Critical Care Medicine - Imam Khomeini Hospital Complex - Faculty of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Khalili, Hossein Department of Pharmacotherapy - Imam Khomeini Hospital Complex - Faculty of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Shafiee, Gita Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Ahadi, Zeinab Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Rostami, Mahsa Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Alizad, Saba Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Heshmat, Ramin Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Mohraz, Minoo Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High-Risk Behaviors - Tehran University of Medical Science, Tehran, Iran
Abstract :
Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily.
Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P<0.001) and a significant increase in GCS value (14.46±0.88) compared to the control group (12.86±1.78) (P<0.001). Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07±34.80, control group: 51.75±42.10, P=0.98) and CRP (Septimeb group: 48.86±23.21, control group: 49.93±36.22, P=0.92) decreased, but did not show a significant reduction.
Conclusion: Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients’ mortality rates.
