Massive Hemoptysis due to Isotretinoin in a Young Man

The patient is a young man with no previous history of respiratory diseases who was given 80 mg of Accutane for acne on the face, followed by a massive hemoptysis one day prior to presentation. Chest CT scan was normal and bronchoscopy showed evidence of bleeding in the lower respiratory tract. Patient’s laboratory exams were all normal and after discontinuation of the drug, bleeding stopped and never recurred.