Author/Authors :
Mohammadi, Rasoul Department of Medical Parasitology and Mycology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Meidani, Mohsen Department of Infectious Diseases - Al-Zahra Hospital - Isfahan University of Medical Sciences, Isfahan, Iran , Mostafavizadeh, Kamyar Department of Infectious Diseases - Al-Zahra Hospital - Isfahan University of Medical Sciences, Isfahan, Iran , Iraj, Bijan Department of Endocrinology - Isfahan University of Medical Sciences, Isfahan, Iran , Hamedani, Pooria Department of Endocrinology - Isfahan University of Medical Sciences, Isfahan, Iran , Sayedain, Mohammad Amin Department of Cardiology - Chamran Hospital (Heart Center) - Isfahan University of Medical Sciences, Isfahan, Iran , Mokhtari, Mojgan Department of Pathology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: Rhinocerebral mucormycosis is a fatal infection typically affecting diabetic or immunosuppressed patients. In most cases, infection is caused by inhalation of fungal spores. Mortality rate of patients is very high (40-85%).
Case Presentation: In this study, three diabetic patients with rhinocerebral mucormycosis were presented. The etiologic agents of mucormycosis in two patients were isolated and identified by sequence analysis and data were registered in Gene bank database. Conclusion: In patients with mucoreosis, early detection, surgical excision and appropriate debridement, suitable antifungal therapy, and control of risk factors like diabetes mellitus are the main parameters of successful management of this lethal infection.
