Title of article
Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats
Author/Authors
Haghighi, Bahram Dept. of Clinical Biochemistry - Isfahan University of Medical Sciences , Farsadi, Mahboobeh Dept. of Clinical Biochemistry - Isfahan University of Medical Sciences
Pages
4
From page
103
To page
106
Abstract
Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were
measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue
was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise
in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased
PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme
activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum
triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed
during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in
glycerolipid metabolism. I
Keywords
Phosphohydrolase , Hyperlipidemia , Pregnancy
Journal title
Astroparticle Physics
Serial Year
2001
Record number
2473943
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