Author/Authors :
Assmar, Mehdi Pasteur Institute of Iran , Hajizadeh Manjili, Masoud Razi vaccine and Serum Research Institute Of Iran , Esmaeili-Rastaghi, Ahmad R Pasteur Institute of Iran , Farahmand, Mahin Pasteur Institute of Iran , Piazak, Nourair Pasteur Institute of Iran , Rafati, Sima Pasteur Institute of Iran , Naddaf Dezfool, Saied R Pasteur Institute of Iran
Abstract :
The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH
strain) was investigated. Immunized mice survived challenge infection and displayed increased
interferon gamma (INF-γ) production. On the other hand, nonimmunized controls died after 10 days
and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No
tachyzoites were detected in peritoneal exudates of the immunized mice 10 days after challenge. These
results indicate that the vaccination with γ-irradiated tachyzoites not only protects the mice against
challenge infection, but may circumvent the danger of the vaccine being life-threatening because of
remaining tachyzoites inside macrophages posing as a latent infection. I
