Administration of Large Volume Hypertonic Solutions for Resuscitation of Hemorrhagic Shock in Rabbit

An animal model was designed to study the effect of large volume Hypertonic Solutions (HTS) for re- suscitation following a hypovolemic shock. Resuscitation in hypovolemic animals was performed by infusion of 15 ml/kg of normal saline (group I), 5% sodium bicarbonate (NaHCO3); (group II), 5% sodium chloride (NaCI) and 7.5 % NaHCO3; 1:1 VN (group III), 5% NaC1 (group IV), and 5% NaCl and 5% serum albumin; 2:1 VN (group V) via jugular vein. All animals were monitored sixty minutes post infusion. Then they were sacrificed to determine Brain Water Content (BWC), pathological investigation of heart, aorta and pulmonary tissues. Two other groups were also used for determination of normal BWC (group N) and aftershock BWC (group S). Mean Arterial Pressure (MAP) of groups H, IV and V were statistically different from group I (P <0.05). Albumin concentration and urine output were increased markedly in group V (P <0.05). Serum osmolality in groups III, IV, and V were significantly different from the first group (P <0.05). Acid-base parameters in groups II and III were raised toward normal, and they showed significant differences from group I (P <0.05). BWC were decreased in groups treated with HTS (p <0.05). No statistical differences were observed in pulse pressure, heart and respiration rates, sodium and potassium concentrations, and urine osmolality between the groups. No detectable pathological changes were observed in heart, aorta and pulmonary tissues