Author/Authors :
Ebadi, Ahmad Department of Cardiac Anesthesiology - Golestan Hospital - Ahvaz Jundishapur University of Medical Sciences , Soltanzadeh, Mansour Department of Cardiac Anesthesiology - Golestan Hospital - Ahvaz Jundishapur University of Medical Sciences , Nesioonpour, Sholeh Department of Anesthesiology - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences , Akhondzadeh, Reza Department of Anesthesiology - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences , Dehghani Firoozabadi, Mehdi Department of Cardiac Anesthesiology - Golestan Hospital - Ahvaz Jundishapur University of Medical Sciences , Attariyan, Mansoureh Department of Anesthesiology - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences
Abstract :
Background: According to the previous studies, antihypertensive drugs should be withdrawn before surgery. Nowadays it is accepted that some drugs effectively control systemic blood pressure (BP) to assure its desirable therapeutic control. Objectives: In this study, the effects of captopril, an angiotensin converting enzyme inhibitor (ACEI), on hemodynamic changes before, during and after the coronary artery bypass graft (CABG) surgery was studied. Patients and Methods: In this study, 54 patients were randomly selected in the cardiac surgery ward of Ahvaz Golestan Hospital. Amongst them, 27 patients (control group) did not consume any ACEI for controlling BP but the remained 27 patients (experimental group) used the drugs. In these groups, the effects of captopril on hemodynamic changes before, during and after surgery were studies. Results: Two groups did not have any significant differences in oxygen saturation (P value: before, 0.15; during, 0.08; and after CABG, 0.53) and pulse rate (P value: before, 0.09; during, 0.25; and after CABG, 0.15). Nevertheless, they had significant differences in changes in systolic and diastolic BP in different time points (P Value of systolic BP: before, 0.001; during, < 0.001; and after CABG, 0.007; and P Value of diastolic BP: before, < 0.001; during, 0.001; and after CABG, 0.009). Conclusions: Using ACEI can effectively reduce the systolic and diastolic BP before, during, and after CABG surgery without any effects on oxygen saturation and pulse rate.
