Title of article :
Antioxidant, Antibacterial Activities and General Toxicity of Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas
Author/Authors :
Middleton, Patricia School of Pharmacy - The Robert Gordon University, Scotland , Stewart, Fiona School of Pharmacy - The Robert Gordon University, Scotland , Al-Qahtani, Salem School of Pharmacy - The Robert Gordon University, Scotland , Egan, Paula School of Pharmacy - The Robert Gordon University, Scotland , O’Rourke, Ciara School of Pharmacy - The Robert Gordon University, Scotland , Abdulrahman, Aysha School of Pharmacy - The Robert Gordon University, Scotland , Byres, Maureen School of Pharmacy - The Robert Gordon University, Scotland , Middleton, Moira School of Pharmacy - The Robert Gordon University, Scotland , Kumarasamy, Yashodharan School of Pharmacy - The Robert Gordon University, Scotland , Shoeb, Mohammad School of Pharmacy - The Robert Gordon University, Scotland , Nahar, Lutfun School of Life Sciences - The Robert Gordon University, Scotland , Delazar, Abbas School of Pharmacy - Tabriz University of Medical Sciences, Tabriz , Dey Sarkerd, Satyajit School of Biomedical Sciences - University of Ulster, Northern Ireland
Abstract :
Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas have long been used in folkloric medicine for the treatment of various ailments. As part of our continuing screening of plant extracts for activities, the extracts of A. glutinosa, F. excelsior and P. rhoeas have been screened for their antioxidant and antibacterial activities, as well as their general toxicity towards brine shrimps. Among the extracts, the methanol (MeOH) extract of F. excelsior displayed the highest level of antioxidant activity (RC50=1.35x10-2 mg/mL) and the dichloromethane (DCM) extract of P. rhoeas was the most toxic extract towards brine shrimps (LD50=2.4x10-2 mg/mL). The n-hexane and DCM extracts of F. excelsior and the MeOH extract of A. glutinosa were active (MIC values were within 1.25x10-1 and 1.00 mg/mL) against all 8 bacterial species tested, including methicillin-resistant Staphylococcus aureus (MRSA).
Keywords :
Alnus glutinosa , Fraxinus excelsior , Papavar rhoeas , 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) , Antibacterial , Brine shrimp lethality assay
