Comparative study of chitosan and chitosan–gelatin scafold for tissue engineering

A number of orthopedic disorders and bone defect issues are solved by scafold-based therapy in tissue engineering. The biocompatibility of chitosan (polysaccharide) and its similarity with glycosaminoglycan makes it a bone-grafting material. The current work focus on the synthesis of chitosan and chitosan–gelatin scafold for hard tissue engineering. The chitosan and chitosan–gelatin scafold have shown improved specifc surface area, density, porosity, mechanical properties, biodegradability and absorption. These scafolds can lead to the development or artifcial fabrication of hard tissue alternates. The porous scafold samples were prepared by freeze-drying method. The microstructure, mechanical and degradable properties of chitosan and chitosan–gelatin scafolds were analyzed and results revealed that the scafolds prepared from chitosan–gelatin can be utilized as a useful matrix for tissue engineering.