Pluronic as nano-carier for drug delivery systems

A usual method to build a nano-drug delivery system is incorporating the drug within the nano-carrier to high solubility, improved circulation time, and metabolic stability. However, recent studies indicate that the polymeric nanomaterials can be applied more than the inert carrier functions based on the biological response modifiers. Tri-block copolymers of Pluronic as one of these polymeric materials that they cause different functional alterations within cells. The key characteristic related to the biological activity of Pluronics is their ability to incorporate drug into membranes followed by subsequent translocation into the cells and then affecting the different cellular functions such as ATP synthesis, mitochondrial respiration, activity of drug efflux transporters, gene expression, apoptotic signal transduction and so on. As a result, Pluronics cause effective sensitization to the different anticancer agents based on the multidrug resistant (MDR) and resulting increase in the drug transport across the blood brain and intestinal barriers that it causes transcriptional activation of gene expression both in vitro and in vivo. On the other hand, there is an increasing interest in the area of drug delivery systems by using polymers as carrier for small and large molecules. Particulate systems like polymeric nanoparticles and micelles have been applied as a physical method to improve the pharmacokinetic and pharmacodynamics profiles of the different drug molecules. It is widely that Pluronics are excellent polymer for nano-drug delivery vehicles by different routes of administration due to their wide compatibility with different drug candidates This review is aimed to highlight the Pluronics -based nanomicelles/ nanoparticles that have been developed to date.