Author/Authors :
Barzegar, Mahdi Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Shaygannejad, Vahid Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Mirmosayyeb, Omid Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Valipour, Samane Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Akbari, Roya Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Vesal, Sahar Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Ashtari, Fereshte Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Dehghani, Leila Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Mohammadi, Abdolrasoul Neurosciences Research Center - Alzahra Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Esmaeil, Nafiseh Department of Immunology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: Multiple Sclerosis (MS) is a demyelinating disorder of the Central Nervous System
(CNS). In addition to the role of immune mediated mechanisms, oxidative and nitrosative stress
also play an important role in neuropathology of MS. Bilirubin as an endogenous antioxidant has
neuroprotective effects; however few studies have assessed the association between serum bilirubin
level and MS.
Objectives: To evaluate serum level of bilirubin in MS patients.
Materials and Methods: Serum samples were collected from participants who referred to Kashani
MS clinic in Isfahan between July 2016 and July 2017. A total of 80 MS patients (67 females and
13 males) and 94 Healthy Control subjects (HCs) (62 female and 32 male) enrolled. Compression
of bilirubin levels between MS patients and HCs was done with covariance analysis. Regression
analysis was used to assess the relation between bilirubin concentration and EDSS. SPSS software
version 17.0 for Windows (SPSS, Chicago, IL, USA) was used.
Results: The level of Direct bilirubin (Dbil) was significantly lower in MS patients compared with
HCs (P=0.02). Otherwise the serum concentration of Total bilirubin (Tbil) and in Direct bilirubin
(Ibil) were higher in MS patients, but it was not statistically significant. There was a negative
correlation between Extended Disability Status Scale (EDSS) and bilirubin levels (Tbil, Dbil and
Ibil) but it was not significant.
Conclusion: Bilirubin level is lower in MS patients and deficit of its antioxidant level may play role
in neuropathology of MS.
