Author/Authors :
Hashemi, Mohammad Cellular and Molecular Research Center - Zahedan University of Medical Sciences, Zahedan , Naderi, Mohammad Research Center for Infectious Diseases and Tropical Medicin - Zahedan University of Medical Sciences, Zahedan , Ebrahimi, Mahboubeh Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan , Amininia, Shadi Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan , Bahari, Gholamreza Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan , Taheri, Mohsen 4Genetics of Non-Communicable Diseases Research Center, Zahedan University of Medical Sciences, Zahedan , Eskandari-Nasab, Ebrahim Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan , Ghavami, Saeid Department of Human Anatomy and Cell Science - University of Manitoba, Manitoba, Canada
Abstract :
Macrophages and T-lymphocytes are involved in immune response to Mycobacterium tuberculosis. Macrophage produces interleukin (IL)-1 as an inflammatory mediator. IL-1 receptor antagonist (IL1-Ra) is a natural antagonist of IL-1 receptors. In this study we aimed to examine the possible association between the variable number of tandem repeats (VNTR) of the IL-1 receptor antagonist (IL1RN) gene and pulmonary tuberculosis (TB) in a sample of Iranian population.
Our study is a case-control study and we examined the VNTR of the IL1RN gene in 265 PTB and 250 healthy subjects by PCR.
Neither the overall chi-square comparison of PTB and control subjects nor the logistic regression analysis indicated any association between VNTR IL1RN polymorphism and PTB.
Our data suggest that VNTR IL1RN polymorphism may not be associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are needed to find out the impact of IL1RN VNTR polymorphism on risk of developing TB.
Keywords :
IL1RN , Polymorphism , Tuberculosis , VNTR
