Author/Authors :
Mehdipour, Masoumeh Department of Oral Medicine - Faculty of Dentistry - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Taghavi Zenouz, Ali Department of Oral Medicine - Faculty of Dentistry - Tabriz University of Medical Sciences, Tabriz, Iran , Dastanpour, Somayeh Department of Oral Medicine - Faculty of Dentistry - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Bahramian, Ayla Department of Oral Medicine - Faculty of Dentistry - Tabriz University of Medical Sciences, Tabriz, Iran , Gholizadeh, Narges Department of Oral Medicine - Faculty of Dentistry - Tehran University of Medical Sciences, Tehran, Iran , Azari-Marhabi, Saranaz Department of Oral Medicine - Faculty of Dentistry - Shahid Beheshti University of Medical Sciences, Tehran, Iran 4.
Abstract :
Introduction: Malondialdehyde (MDA) is a useful determinant to show high level of lipid
peroxidation which lead to impaired cell function. Previous studies have mentioned there is a
relationship between high oxidative stress and low anti-oxidant activity in patients with oral lichen
planus. The aim of this study was to evaluate serum level of Malondialdehyde as an indicator of
oxidative stress in patients with oral lichen planus which is a chronic inflammatory disease with
unknown etiology.
Materials & Methods: This descriptive-comparative study evaluated the oxidative stress status on
twenty patients with oral lichen planus and 20 control healthy individuals based on serum level of
Malondialdehyde.
Results: The mean serum Malondialdehyde levels in oral lichen planus patients and control
individuals were 2.9 (±2) and 2.4 (±1.3) μg/ml, respectively, indicating no significant difference
(P=0.6).
Conclusion: According to the results, role of Malondialdehyde in cellular damage and
pathogenesis of oral lichen planus was not proved.
