Author/Authors :
Karimi, Ahmad Departments of Biostatistics and Epidemiology - School of Public Health - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Namayandeh, Mahdieh Departments of Biostatistics and Epidemiology - School of Public Health - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Fallahzadeh, Hossein Departments of Biostatistics and Epidemiology - School of Public Health - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Majidpour, Fatemeh Departments of Biostatistics and Epidemiology - School of Public Health - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Mohammadhoseini, Mojtaba Departments of Biostatistics and Epidemiology - School of Public Health - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Askari, Maryam Yazd Cardiovascular Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Sadr Bafghi, Mahmood Yazd Cardiovascular Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Soltani, Mohammadhosein Yazd Cardiovascular Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Hadiani, Leila Yazd Cardiovascular Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Jalilian, Samaneh Yazd Cardiovascular Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Sareban-Hassanabadi, Mohammad-Taghi Yazd Cardiovascular Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Rahmanian, Masoud Diabetes Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran
Abstract :
Introduction: Regarding the high impact of Diabetes Mellitus type II (DM II)
on human's health, it seems that identifying DM II risk factors is important to
prevent its development. Further studies are needed to ensure the positive role of
uric acid in the onset of diabetes. This study targeted at investigating the
attributed risk of hyperuricemia for the onset of DM II.
Methods: In the present study, 1641 non-diabetic people, selected through
multi-stage random cluster sampling, were followed up for 10 years (2006 -
2016). During the study, data on the variables of the study were collected and
entered in SPSS 16 which was used to analyze the data. To calculate the
attributions of hyperuricemia in the risk of developing diabetes, Levin's
formulas and attributed risk related to the prevalence of exposure during these
ten years were used.
Results: Findings showed DM II was developed in 54.8% of people with
hyperuricemia, whereas 28.2% of people with normal uric acid level developed
diabetes. The Population Attributed Risk (PAR) of hyperuricemia and uric acid
over than 75th percentile of serum uric acid for DM II incidence were calculated
by the weighted attributed risk formula was 3.6 % and 24.2 %, respectively.
With the treatment of hyperuricemia or serum uric acid over than 75th percetile,
the incidence of diabetes in population was reduced up to 3.6% or 24.2% over a
10-year period respectively.
Conclusion: In this study, there was a significant correlation between high uric
acid level and the risk of diabetes. Therefore, necessary measurements should be
taken to treat the hyperuricemia patients in order to prevent the incidence of
diabetes caused by high blood acid uric.
Keywords :
Incidence , Hyperuricemia , Diabetes Mellitus , Risk
