Author/Authors :
Khalaji, Naser Department of Physiology - Faculty of Medicine - Urmia University of Medical Sciences , Khaffafi, Behrang Department of Emergency Medicine - Urmia University of Medical Sciences , Seyed Mokhtari, Arman Student Research Committee - Faculty of Medicine - Urmia University of Medical Sciences , Karimipour, Mojtaba Department of Anatomy - Faculty of Medicine - Urmia University of Medical Sciences , Alizadeh, Hamed Student Research Committee - Faculty of Medicine - Urmia University of Medical Sciences
Abstract :
Background: Nowadays, the rapid recovery of skin lesions and
functional return are among the goals of researchers. The skin
is the first defensive barrier against microorganisms in the body
and its failure causes infection to spread in all systems of the
body. By taking into account the contradictory results of previous
studies on the impact of phototherapy on wound healing and
also the considerable anti-oxidative properties of curcumin, this
novel study was carried out with the aim of determining the
histopathological impact of compact fluorescent light (CFL) and
curcumin on the process of wound healing.
Methods: Forty-eight adult male wistar rats were randomly
divided into four groups. The control group received 2.0 ml
of ethyl oleate, and the curcumin group received only 0.2 ml
curcumin daily for 15 days via intraperitoneal injection. The
fluorescent group received 0.2 ml of ethyl oleate daily for 15 days
via intraperitoneal injection, and were exposed to CFL for 12
hours per day for 15 days. The curcumin plus fluorescent group
received 0.2 ml curcumin daily for 15 days via intraperitoneal
injection, and were exposed to CFL for 12 hours per day for 15
days. The size of the wound was measured by a scale ruler, and
the morphology of the wound site was assessed. Results: The results of this study showed that the best percentage
of repair was observed in the fluorescent group on days 6 and
15 (50±5 and 90±2, respectively), while the least repair was seen
in the group receiving fluorescent plus curcumin (33±7). In
the curcumin group, the wound healing was, not significantly
(P=0.872) reduced on the sixth day, compared to the control
group, whereas compared to the fluorescent and fluorescent
plus curcumin groups, the reduction was significant (P˂0.0001
and P=0.05, respectively). On the fifteenth day, however, the
wound healing was significantly decreased in the curcumin
group compared to the control and fluorescent groups (P˂0.0001
and P˂0.0001 respectively), while it was significantly increased
compared to the fluorescent plus curcumin group (P˂0.0001).
In the fluorescent plud curcumin group, the wound healing
was significantly reduced compared to the other groups on the
fifteenth day (P˂0.0001).
Conclusion: Fluorescent alone resulted in wound healing, in
contrast to the control and curcumin plus fluorescent groups.
Accelerating the repair in this group is likely due to the increase
in blood flow and helping the homeostasis to return to its primary
state. The absence of wound healing in the curcumin group is
probably due to the high dose of curcumin. Moreover, in the
fluorescent plus curcumin group, the causes of no wound healing
and weight loss were probably disorders in the inflammation
process and spread of infection.
Keywords :
wound , wound healing , compact fluorescent lamps , curcumin
