Title of article :
Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
Author/Authors :
Haghighi, Fatemeh Department of Gynecology and Obstetrics - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Kamali, Mahdieh Department of Perinatology - School of Medicine - Tehran University of Medical Sciences - Tehran, Iran , Hantoushzadeh, Sedigheh Department of Perinatology - School of Medicine - Tehran University of Medical Sciences - Tehran, Iran , Borna, Sedigheh Maternal-Fetal and Neonatal Research Center - Tehran University of Medical Sciences - Tehran, Iran , Neamatzadeh, Hossein Department of Medical Genetics - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Mazaheri, Mahta Department of Medical Genetics - Shahid Sadoughi University of Medical Sciences - Yazd, Iran , Noori-Shadkam, Mahmood Mother and Newborn Health Research Center - Shahid Sadoughi University of Medical Sciences - Yazd, Iran
Abstract :
Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss
(RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes
polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL
risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles
published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199,
1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR
A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant
increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A
as well as PAI-1 4G/5G polymorphisms were associated with RPL risk in the Iranian population.
Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population.
Keywords :
Meta-analysis , Prothrombin , Factor V leiden , Thrombophilia , Recurrent miscarriage
Journal title :
Astroparticle Physics
