Title of article :
The Effect of Endurance Training with Crocin Consumption on IGF-1 and Glycogen Expression in Rat Hippocampus Tissue of Trimethyltin-Treated Model of Alzheimer’s Disease
Author/Authors :
Negarandeh, Zahra Department of Physical Education and Sport Sciences - Sanandaj Branch Islamic Azad University, Sanandaj, Iran , Salamat, Khalid Mohamadzadeh Department of Physical Education and Sport Sciences - Sanandaj Branch Islamic Azad University, Sanandaj, Iran , Hosseini, Ali Department of Sport Physiology - Marvdasht Branch Islamic Azad University, Marvdasht, Iran , Etemad, Zaher Department of Physical Education and Sport Sciences - Sanandaj Branch Islamic Azad University, Sanandaj, Iran
Abstract :
Objectives: Alzheimer’s disease is one of the most common causes of dementia with metabolic disorders in the nervous system.
Nutrition and physical activity are two main factors in the management of this disease. The aim of the present study was to investigate
the effect of endurance training with crocin consumption on IGF-1 and glycogen expression in rat hippocampus tissue of a
trimethyltin-treated model of Alzheimer’s disease.
Methods: In this experimental study, 30 male rats were selected and divided into 5 groups of 6 rats including (1) healthy control,
(2) Alzheimer’s control, (3) endurance training, (4) crocin and (5) endurance training with crocin. At first, rats in groups 2 - 5 were
induced Alzheimer’s disease by intraperitoneal injection of 8 mg/kg of trimethyltin. Then, during 8 weeks, rats in groups 3, 5, ran
on treadmill for 3 sessions per week, each session 15 - 30 minutes at speeds of 15 - 20 m/min and groups 4 and 5 received 25 mg/kg of
crocin daily. The results were analyzed by Shapiro-Wilk test and one-way ANOVA with Tukey post hoc (P0.05).
Results: Alzheimer’s induction with trimethyltin had a significant effect on reduction of IGF-1 gene expression (P = 0.001) and glycogen
(P = 0.001); endurance training had a significant effect on increase of IGF-1 (P = 0.001) and glycogen (P = 0.001); crocin consumption
had no significant effect on IGF-1 (P = 0.48) and glycogen (P = 0.39); endurance training with crocin consumption had significant
effect on increase of IGF-1 (P = 0.001) and glycogen (P = 0.02) as well as endurance training (P = 0.001) and endurance training with
crocin consumption rather than crocin consumption had significant effect on increase of IGF-1.
Conclusions: Although endurance training results in a significant increase in IGF-1 and glycogen in the hippocampus tissue of
Alzheimer’s rats, nonetheless, the use of crocin in combination with endurance training rather than crocin consumption alone can
have a greater effect on increased IGF-1 content of the hippocampus in rats with Alzheimer’s.
Keywords :
Alzheimer , IGF-1 , Glycogen , Crocin , Training
Journal title :
Astroparticle Physics
