Author/Authors :
Shahidi-Dadras, Mohammad Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Asadi Kani, Zahra Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Yousefi, Maryam Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Jaffari Fesharaki, Reza Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Abdollahimajd, Fahimeh Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Razavi, Seyed-Mostafa Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
e hereby report a 79-year-old Iranian man presenting with
nail dystrophy and subsequent development of purpuric and
ecchymotic plaques, hemorrhagic bullae, and infiltrated papules on
the head, neck and trunk. Histological examination of the gingiva,
bone marrow aspiration, and biopsy confirmed the diagnosis of
primary systemic amyloidosis. In this case, nail dystrophy was
the presenting sign of primary systemic amyloidosis, which is a
recognized but rare manifestation of this disorder. According to
this case report, we could suggest that nail dystrophy may provide
a clue for early diagnosis of primary systemic amyloidosis, which
would ultimately increase the survival of the patient.
Keywords :
nail dystrophy , multiple myeloma , primary presentation , systemic amyloidosis
