Author/Authors :
Banihashemi, Mahnaz Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Javidi, Zari Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Khani, Fatemeh Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Ghiasi-Moghadam, Taghi Department of Pathology - Mashhad University of Medical Sciences, Mashhad , Ghaffarzadegan, Kamran Department of Pathology - Mashhad University of Medical Sciences, Mashhad , Hashemzadeh, Sara Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad
Abstract :
Background: Pityriasis rosea (PR) is a common papulosquamous
skin disorder that is suspected to have an infectious etiology.
We aimed to study the role of human herpesvirus-6 (HHV-6) in
the pathogenesis of PR.
Method: We used immunohistochemical (IHC) assays to detect
HHV-6 in patients with PR. Fifty-one patients with PR and 35 age
and sex matched healthy control samples were enrolled in the
study. The intensity and percentage of cell staining for HHV-6
infection were evaluated and recorded.
Result: The intensity of IHC staining was negative in 25 (49.01%)
patients and 24 (68.58%) control samples while it was +1 in 6
(11.77%) patients and 11 (31.42%) control samples, +2 in 4 (7.85%)
patients and +3 in 16 (31.37%) of them. The incidence of moderate
and intense staining for HHV-6 was significantly higher among
patients with PR than the control group (P value < 0.01).
Conclusion: We concluded that HHV-6 infection may play a
role in some patients with PR. The rate of HHV-6 infection was
significantly higher in PR patients than the control group.
