Author/Authors :
Kamyab, Kambiz Department of Pathology - Tehran University of Medical Sciences, Tehran , Firooz, Alireza Center for Research and Training in Skin Diseases and Leprosy - Tehran University of Medical Sciences, Tehran , Montaser Kohsari, Laleh Center for Research and Training in Skin Diseases and Leprosy - Tehran University of Medical Sciences, Tehran , Noorian, Negin Center for Research and Training in Skin Diseases and Leprosy - Tehran University of Medical Sciences, Tehran , Khorram Khorshid, Hamidreza Undersecretary of Research - Ministry of Health, Tehran , Khatami, Alireza Center for Research and Training in Skin Diseases and Leprosy - Tehran University of Medical Sciences, Tehran , Rajabi Estarabadi, Ali Center for Research and Training in Skin Diseases and Leprosy - Tehran University of Medical Sciences, Tehran
Abstract :
Background: In 10-30% of the cases with sarcoidosis, skin lesions
appear solely without any systemic signs or symptoms. BTNL2
gene, which is a member of the immunoglobulin gene super family
and is associated with CD86 and CD80 co-stimulatory receptors,
is identified to play an important role in the establishment of
sarcoidosis. We aimed to evaluate the role of this gene in patients
with skin sarcoidosis in comparison with skin sarcoidal reaction
patients and those with normal skin.
Methods: The nucleotide sequence of rs2076530 allele in exon
5 of BTNL2 gene was compared among the paraffin-embedded
blocks of 34 patients with a histologic diagnosis of sarcoidosis, 14
patients with skin sarcoidal reaction (tattoo, foreign body), and
27 patients with normal skin (excised during cosmetic surgery)
using polymerase chain reaction.
Results: There was no statistically significant difference in the
frequency of 3 genotypes of AA, AG, and GG in rs2076530 allele
among skin sarcoidosis, skin sarcoidal reaction, and normal skin.
Conclusion: The expression of rs2076530 allele of BTNL2 gene
in skin sarcoidosis or sarcoidal reaction does not differ with its
expression in the normal skin.
