Author/Authors :
FARAHBAKHSH-FARSI, Payam Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , DJAZAYERY, Abolghassem Dept. of Community Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , ESHRAGHIAN, Mohammad Reza Dept. of Biostatistics - School of Public Health - Tehran University of Medical Sciences, Tehran , KOOHDANI, Fariba Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , ZAREI, Mahnaz Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , JAVANBAKHT, Mohammad Hassan Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , DERAKHSHANIAN, Hoda Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , DJALALI, Mahmoud Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran
Abstract :
Background: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients.
Methods: Forty-five type 2 diabetic patients from Iranian Diabetic Association in Tehran, Iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. Blood samples, food intake records, anthropometric measurements were obtained from all participants at the begin-ning and end of the study.
Results: Fasting RBP 4 plasma levels significantly changed after 10 wk supplementation (P = 0.01). The LCN 2 con-centrations decreased in omega-3 group, but the changes were not statistically significant. Omega-3 supplementation had no noticeable effect on anthropometric factors.
Conclusions: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM.
Keywords :
Omega-3 fatty acid , Lipocalin , Retinol-binding protein , Diabetes mellitus
