Author/Authors :
Saadati, Saeede Faculty of Nutrition and Food Technology - Department of Clinical Nutrition and Dietetics - Shahid Beheshti University of Medical Sciences, Tehran , Hekmatdoost, Azita Faculty of Nutrition and Food Technology - Department of Clinical Nutrition and Dietetics - Shahid Beheshti University of Medical Sciences, Tehran , Mansour, Asieh Faculty of Nutrition and Food Technology - Department of Clinical Nutrition and Dietetics - Shahid Beheshti University of Medical Sciences, Tehran , Yari, Zahra Faculty of Nutrition and Food Technology - Department of Clinical Nutrition and Dietetics - Shahid Beheshti University of Medical Sciences, Tehran , Hatami, Behzad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Sadeghi, Amir Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Hedayati, Mehdi Cellular and Molecular Endocrine Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Aim: The aim of this study was to examine the effects of curcumin supplementation on hepatic fibrosis using different fibrosis assessment methods.
Background: Nonalcoholic fatty liver disease (NAFLD) may progress to hepatic fibrosis. Detection of hepatic fibrosis should be measured by liver biopsy, which is an invasive method. Thus, some non-invasive methods are suggested.
Methods: Hepatic fibrosis was evaluated in forty six patients with NAFLD before and three months after supplementation with 1.5 gram curcumin or placebo. Methods of assessments included fibroscan, and calculating non-invasive marker panel including FIB-4 (Fibrosis4), NFS (NAFLD fibrosis score), APRI (AST (Aspartate aminotransferase) Platelet Ratio Index), and BARD (body mass index, AST/ALT (Alanine aminotransferase ratio, diabetes).
Results: Fibrosis score was reduced significantly after curcumin supplementation using fibroscan (p<0.01), FIB-4 (p<0.05) and APRI
(p<0.05) tests, while fibrosis score did not change significantly using BARD and NFS methods (p>0.05).
Conclusion: Our results revealed that fibroscan, FIB-4, and APRI are similar in assessment of hepatic fibrosis changes after curcumin supplementation. Future studies with higher sample sizes are needed to confirm these results.
