Title of article :
The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats
Author/Authors :
Roghani, Mehrdad Department of Physiology - Medicinal Plant Research Center - School of Medicine - Shahed University,Tehran , Baluchnejadmojarad, Tourandokht Department of Physiology - School of Medicine - Iran University of Medical Sciences, Tehran , Roghani Dehkordi, Farshad Department of Cardiology and Internal Medicine - School of Medicine - Shahrekord University of Medical Sciences, Tehran
Abstract :
In this study, the possible involvement of L-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. Addition of quercetin (0.1 µM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings and nifedipine attenuated this response, especially for noradrenaline (P<0.05). It is concluded that the flavonoid quercetin produces a potent relaxation of the rat aorta and blockade of voltage-operated calcium channels could attenuate this effect.
Keywords :
Quercetin , Aorta , Calcium channel , Rat
Journal title :
Astroparticle Physics
