Title of article :
Intracerebroventricular Injection of Histamine Induces State-Dependency through H1 Receptors
Author/Authors :
Zarrindast, Mohammad Reza Department of Pharmacology - School of Medicine and the Iranian National Center for Addiction Studies - Tehran University of Medical Sciences, Tehran , Malekmohamadi, Nazanin Department of Pharmacology - School of Medicine and the Iranian National Center for Addiction Studies - Tehran University of Medical Sciences, Tehran , Fazli Tabaei, Soheila Department of Physiology - Tehran Medical Unit Islamic Azad University, Tehran , Ahmadi, Shamseddin Department of Animal Sciences - School of Biology - University College of Science - Tehran University, Tehran
Abstract :
The aim of the present study was to investigate whether and by which mechanism; histamine can induce state-dependent retrieval of passive avoidance task. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20µg/mouse) impaired retrieval, when it was tested 24 h later. In the animals, which retrieval was impaired due to histamine pre-training administration, pre-test administration of histamine, with the same dose, restored retrieval. The H1 blocker, pyrilamine (20 µg/mouse, i.c.v.), but not the H2 blocker; ranitidine prevented the restoration of retrieval by pre-test histamine. A pre-test administration of histamine H3 receptor antagonist, clobenprobit, also reversed hitamine-induced impairment of memory retention. In conclusion, histamine can induce state-dependent retrieval through the H1 receptor H1 mechanism.
Keywords :
Histamine , Histamine receptor antagonist , Memory , State-dependent retrieval , Mouse
Journal title :
Astroparticle Physics
