Author/Authors :
Nasserinejad, Maryam Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Rezasoltani, Sama Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Shojaee, Sadjad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Yaghoob-Taleghani, Mohammad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Pourhoseingholi, Mohamad Amin Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Nazemalhosseini-Mojarad, Ehsan Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Akbari, Setareh Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Baghestani, Ahmad Reza Faculty of Paramedical Sciences - Department of Biostatistics - Physiotherapy Research Center - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Colorectal cancer (CRC) presents as one of the most common cancers burden worldwide. It is the third most commonly diagnosed malignancy and the fourth
leading cause of cancer-related death in the world (1). In Iran, CRC is the fourth leading cause of cancer death (2). Unfortunately, not only incidence of CRC has
increased in both sexes during the last decade, but also the mortality rate of CRC slightly increased (3, 4). In most cases, CRC is produced through two main
molecular pathways. One inhibitory pathway created by successive mutations in tumor suppressor genes and oncogenes and the mutation pathway detected by the
defect in the DNA repair mismatch pair genes (5, 6). Exonuclease 1 (Exol) is the only exonocytic involved in the human MMR system. Due to the specific role of
Exol in the MMR system, this gene is a predisposing factor in CRC (7-9)
Keywords :
Colorectal Cancer , CRC , Tumor , MMR system
