Single-nucleotide polymorphism of Exo1 gene is associated with risk of colorectal cancer based on robust Bayesian approach

Colorectal cancer (CRC) presents as one of the most common cancers burden worldwide. It is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death in the world (1). In Iran, CRC is the fourth leading cause of cancer death (2). Unfortunately, not only incidence of CRC has increased in both sexes during the last decade, but also the mortality rate of CRC slightly increased (3, 4). In most cases, CRC is produced through two main molecular pathways. One inhibitory pathway created by successive mutations in tumor suppressor genes and oncogenes and the mutation pathway detected by the defect in the DNA repair mismatch pair genes (5, 6). Exonuclease 1 (Exol) is the only exonocytic involved in the human MMR system. Due to the specific role of Exol in the MMR system, this gene is a predisposing factor in CRC (7-9)