Author/Authors :
Akbari, H. Department of Biostatistics and Epidemiology- Kashan University of Medical Sciences, Kashan , Piroozmand, A. Department of Microbiology-Faculty of Medicine- Kashan University of Medical Sciences, Kashan , Dadgostar, E. Halal Research Center of IRI-FDA, Tehran , Nikoueinejad, H. Nephrology and Urology Research Center- Baqiyatallah University of Medical Sciences, Tehran , Chitsazian, Z. Department of Internal Medicine- Kashan University of Medical Sciences, Kashan , Einollahi, B. Nephrology and Urology Research Center- Baqiyatallah University of Medical Sciences, Tehran , Amini Mahabadi, J. Gametogenesis Research center- Kashan University of Medical Sciences, Kashan
Abstract :
Background: Transfusion-transmitted virus (TTV) is a single-stranded DNA virus. Renal transplant patients
have a higher risk of TTV infection.
Objective: To evaluate the prevalence of TTV and its correlation with post-renal transplantation complications
in a population of Iranian patients.
Methods: A cross-sectional study was performed on 120 renal transplant recipients. TTV infection in the
peripheral blood samples was detected by semi-nested polymerase chain reaction (semi-nested PCR).
Then, the relationship between TTV and renal post-transplant complications was examined.
Results: 34.2% renal transplant recipients were positive for TTV. There was a significant correlation between
the presence of TTV and diabetes, acute transplant rejection, and urinary tract infection. We did
not find any direct correlation between the presence of TTV infection and hypertension, hyperlipidemia,
respiratory tract infection, and cytomegalovirus infection.
Conclusion: We found an increased rate of TTV infection in renal transplant recipients associated with
post-transplantation complications. TTV may be an important risk factor for some post-renal transplantation
complications.
