Author/Authors :
Jarrahpour, Aliasghar Department of Chemistry - College of Sciences - Shiraz University, Shiraz , Heiran, Roghayeh Department of Chemistry - College of Sciences - Shiraz University, Shiraz , Sinou, Véronique Faculte´ de Pharmacie - Aix-Marseille Universite´, France , Latour, Christine Faculte´ de Pharmacie - Aix-Marseille Universite´, France , Djouhri Bouktab, Lamia Faculte´ de Pharmacie - Aix-Marseille Universite´, France , Michel Brunel, Jean Faculte´ de Pharmacie - Aix-Marseille Universite´, France , Sheikh, Javed Department of Chemistry - Dhote Bandhu Science College, India , Ben Hadda, Taibi Laboratoire de Chimie des Matériaux - Département de Chimie - Facultés des Sciences - Université Mohammed Premier, Morocco
Abstract :
Some new b-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino b-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC50 values.
Keywords :
β-Lactam , 2-Azetidinones , Acylation , Antimalarial activities , POM analyses
