Title of article :
Determination of Sulfasalazine in Sulfasalazine Tablets Using Silver Nanoparticles
Author/Authors :
Ramezani, Zahra Nanotechnology Research center - Faculty of Pharmacy - Jundishapur University of Medical Sciences, Ahvaz , Dibaee, Najmeh Chemistry Department - Research and Science Center of Azad University - Ahvaz Branch, Ahvaz
Abstract :
Resonance light scattering (RLS) intensity of silver nanoparticles in the presence
of sodium dodecylsulphate was quenched on addition of sulfasalzine. The quenching
extent was shown to be proportional to the sulfasalazine concentration. Effect of
different parameters such as pH, volume and kind of buffer, silver nanoparticles
concentration, sodium dodecylsulphate (SDS) concentration, and waiting time on
RLS quenching were investigated. Calibration curve was linear in the range of 10
to 70 μg ml-1. Detection limit was determined as 0.012 mg.ml-1. The method was
successfully applied to the determination of sulfasalazine in different batch numbers
of sulfasalazine tablets. The results were compared with those determined by USP
method. Reasonable agreements were observed.
Keywords :
Resonance light scattering , Silver nanoparticles , Sulfasalazine
Journal title :
Astroparticle Physics
