Title of article
Lethality Assay of Radiopharmaceutical bis-Thiosemicarbazones Using Brine Shrimp (Artemia salina) Test
Author/Authors
Novinrooz, Aytak Radiopharmaceutical Research and Development Lab (RRDL) - Nuclear Science and Technology Research Institute (NSTRI), Tehran , Sadraee, Sahar Faculty of Pharmacy - Azad Islamic University, Tehran , Jalilian, Amir Reza Research Institute for Nuclear Medicine - Tehran University of Medical Sciences, Tehran , Heydarieh, Marzieh Radiopharmaceutical Research and Development Lab (RRDL) - Nuclear Science and Technology Research Institute (NSTRI), Tehran , Akhlaghi, Mehdi Radiopharmaceutical Research and Development Lab (RRDL) - Nuclear Science and Technology Research Institute (NSTRI), Tehran
Pages
5
From page
197
To page
201
Abstract
In the present study, aqueous solutions of some copper-complexing ligands
were screened for their cytotoxicity using brine shrimp lethality test. Among the
ligands tested, diacetyl-bis(N4-methylthiosemicarbazones) (ATSM) proved to be the
most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde
Bis(N4-methyl)thiosemicarbazone (PTSM) was shown to possess low toxicity (7%
lethality at 10 ppm) and glyoxal-bis-thiosemicarbazone (GTS) proved to be a toxic
compound even at 1 ppm (20% lethality). An interesting structure-toxicity relationship
was observed for the ligands based on their water solubility leading to more toxicity
which can be related to polysaccharide crustae of the shrimps. Considering the 1-
10 ppm to be the maximum possible concentration of the ligands in the final
pharmaceutical samples, the safety of these ligands are ATSM>PTSM>GTS.
Keywords
Brine shrimp , Cytotoxicity , Radiopharmaceutical , bis-Thiosemicarbazones
Journal title
Astroparticle Physics
Serial Year
2012
Record number
2481784
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