Title of article :
A Review of Cutaneous Squamous Cell Carcinoma Epidemiology, Diagnosis, and Management
Author/Authors :
Kabir, Soodeh Department of Dermatology - Guilan University of Medical Sciences, Rasht, IR Iran , Schmults, Chrysalyne D Department of Dermatology - Brigham andWomen’s Hospital - Harvard Medical School, Boston, USA , Ruiz, Emily S Department of Dermatology - Brigham andWomen’s Hospital - Harvard Medical School, Boston, USA
Abstract :
Context: Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and its incidence continues
to rise worldwide. While the majority of CSCCs have excellent prognosis, a subset have the propensity to cause poor outcomes.
Evidence Acquisition: A thorough Pubmed search was done and a collection of CSCC-relevant articles were selected based on the
expert opinion.
Results: A number of high-risk factors have been identified including perineural invasion (PNI), desmoplastic growth pattern, poor
differentiation, high risk location and large diameter. Various staging systems have been developed based on these high-risk factors.
Radiologic imaging is important for high-stage tumors and is likely associated with more aggressive management.
Conclusions: Although surgical management is the gold standard, newer therapies such as programmed cell death protein-1 (PD-1)
inhibitors show promise for locally advanced or metastatic disease. Despite advances in treatment, early diagnosis and prevention
of CSCC is still the most important measure to ensure good outcomes.
Keywords :
Skin , Squamous Cell Carcinoma , Review
Journal title :
Astroparticle Physics