Title of article :
The Study of SAD1/UNC-84 Domain Protein 1 in Muscle of Diabetic Male Wistar Rats
Author/Authors :
Bostani, Mehdi Department of Physical Education - Ahvaz Branch - Islamic Azad University, Ahvaz , Rahmati, Masoud Department of Physical Education and Sport Sciences - Faculty of Literature and Human Sciences - Lorestan University, Khoramabad
Abstract :
Objective: The purpose of this study was to measure the changes
of the SUN1 protein levels on soleus muscle in diabetic male wistar
rats.
Materials and Methods: Twenty male Wistar rats with 10
weeks old and weighing 200-250 grams were selected. After two
weeks, the rats were divided into two groups (diabetic group and
healthy group). After 12 hours fasting, diabetes was induced by
intraperitoneally injection of streptozotocin (STZ). At the end of
sixth week, the soleus muscle was removed and kept at a temperature
of -80 degrees to evaluate the difference of SUN1 protein between
two groups.
Results: there was not significant difference in SUN1 protein levels
between diabetic and control groups (P-value: 0.525).
Conclusion: Although in most of laminopathies, the SUN1 protein
that located in the inner nuclear membrane changed, but it seems the
proteins in the inner membrane, are not affected by diabetes.
Keywords :
LINC complex , SUN proteins , Diabetes mellitus , Soleus muscle , Rats
Journal title :
Astroparticle Physics
