Title of article :
Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension
Author/Authors :
Nekooeian, Ali Akbar Department of Pharmacology - Faculty of Medicine - Shiraz University of Medical Science , Khalili, Azadeh Department of Pharmacology - Faculty of Medicine - Shiraz University of Medical Science , Javidnia, Katayoun Medicinal & Natural Products Chemistry Research Centre - Shiraz University of Medical Sciences , Mehdipour, Ahmad Reza Medicinal & Natural Products Chemistry Research Centre - Shiraz University of Medical Sciences , Miri, Ramin Medicinal & Natural Products Chemistry Research Centre - Shiraz University of Medical Sciences
Abstract :
Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. In this study, antihypertensive effects of 5 newly synthesized derivatives of DHP was examined the in rat model of two-kidney, one-clip renal hypertension. The results showed that those compounds containing two nitroxy groups had less decreasing effect on MAP (Men Arterial Pressure) compared to those having one nitroxy group in 5 position. On the other hand, conformational analysis indicated that in two compounds with two chains (A and E), a great steric hindrance existed; therefore, steric hindrance is the most important factor for interaction of compounds with their receptors.
Keywords :
two-kidney , one-clip hypertension , 1,4-dihydropyridines , MAP
Journal title :
Astroparticle Physics
