Title of article :
Anti-nociceptive Activity of Aqueous-methanolic Extract of Phytolacca americana Growing in Iran
Author/Authors :
Karami, Mohammad Pharmaceutical Sciences Research Center and School of Pharmacy - Medical Sciences University of Mazandaran , Saeidnia, Soodabeh Medical Plants Research Center - Tehran University of Medical Sciences , Shahabi majd, Naghi Physiology and Pharmacology Department - School of Medicine - Medical Sciences University of Mazandaran , Ebrahimzadeh, Mohammad Ali Pharmaceutical Sciences Research Center and School of Pharmacy - Medical Sciences University of Mazandaran , Omrani, Neda Pharmaceutical Sciences Research Center and School of Pharmacy - Medical Sciences University of Mazandaran , Salarian, Asieh Resalat Health Center - Medical Sciences University of Mazandaran
Abstract :
Abstract Anti-nociceptive activity of aerial parts of Phytolacca americana were investigated, using the hot plate method in mice. Results of the present study showed that the aqueous methanolic extract of aerial parts of P. americana produced a statistically significant increase in pain threshold after 30 min, in comparison with the control, at adose of 190 mg kg-1 (P<0.001). The activity was comparable to that of morphine (30 mg kg-1 i.p., p> 0.05). The anti-nociceptive activity of P. americana increased until the 60th min (P<0.05 compared to morphine). The results of this study support the extensive use of P. americana in Western Asia and America. The LD50 of extract following a 14 days acute toxicity study was calculated to be 208 mg kg-1 i.p.
Keywords :
Antinociception , Phytolacca americana , Hot plate method , aqueous extract , morphine
Journal title :
Astroparticle Physics
