Author/Authors :
Mba’ning ، Brice M. Department of Organic Chemistry - Faculty of Science - University of Yaoundé 1 , Ateba ، Joël E. T. Department of Organic Chemistry - Faculty of Science - University of Yaoundé 1 , Awantu ، Angelbert F. Department of Chemistry - Faculty of Science - University of Bamenda , Amaral ، Luciana S. Departamento de Química - Universidade Federal de São Carlos , Happi ، Gervais M. Department of Chemistry - Higher Teacher Training College - University of Yaoundé 1 , Neumann ، Beate Department of Chemistry - Faculty of Chemistry - Bielefeld University , Stammler ، Georg Department of Chemistry - Faculty of Chemistry - Bielefeld University , Lenta ، Bruno Department of Chemistry - Higher Teacher Training College - University of Yaoundé 1 , Ngouela ، Silvère A. Department of Organic Chemistry - Faculty of Science - University of Yaoundé 1 , Malavazi ، Iran Departamento de Genética e Evolução - Universidade Federal de São Carlos , Tsamo ، Etienne Department of Organic Chemistry - Faculty of Science - University of Yaoundé 1 , Sewald ، Norbert Department of Chemistry, Organic and Bioorganic Chemistry - Bielefeld University , Rodrigues-Filho ، Edson Departamento de Química - Universidade Federal de São Carlos
Abstract :
One 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), mangiferin (7), β-sitosterol- 3-O-β-D-glucopyranoside (8), friedelin (9), 30-hydroxyfriedelin (10), salaspermic acid (11), 22β-epi-maytenfolic acid (12), orthosphenic acid (13), maltose (14), D-mannitol (15), cangoronine (16), 7-hydroxyfriedelane-1,3-dione (17), tingenone (18), pristimerin (19), α-amyrin acetate (20), β-sitosterol (21), stigmasterol (22), 21-hydroxyfriedelan-3- one (23), abruslactone A (24) and 2α-hydroxypopulnonic acid (25). The structures of the isolated compounds were established by means of spectroscopic analysis. In addition, the structure of (1) was confirmed by its X-ray diffraction. Compounds (1), (7), (10)- (11), (13), (16)-(19) and (25) were evaluated for their antimicrobial activities. Compound (18) showed a significant activity against Staphylococcus aureus (MIC=23.8 μM), while compounds (11) and (19) exhibited moderate inhibiting effect against Staphylococcus aureus (MIC=53.8 μM) and Candida glabrata (MIC=105.9 μM), respectively.
Keywords :
Salacia nitida (Benth.) N.E.Br , leaves and liana , benzophenone , NMR spectroscopy , X , ray diffraction , Antimicrobial Activity
