Title of article :
Betamethasone Can Significantly Decrease Level of Striatal Glutamate in Animal Model of Parkinson’s Disease
Author/Authors :
Shafiee Ardestani, Mehdi Department of Medicinal Chemistry and Radiopharmacy - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran , Fathi-Moghaddam, Hadi Department of Physiology and Physiology Research Center - Jondishapour University of Medical Sciences, Ahwaz
Abstract :
In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p<0.05) in the level of striatal glutamate between treated and non-treated damaged rats.
Keywords :
Microdialysis , Betamethasone , Glutamate , Parkinson’s disease , Rat Model
Journal title :
Astroparticle Physics
