Title of article :
Hemoglobinopathies in Iran: An Updated Review
Author/Authors :
Nasiri, Abolfazl Department of Clinical Biochemistry - Kermanshah University of Medical Sciences, Kermanshah , Rahimi, Zohreh Department of Clinical Biochemistry - Kermanshah University of Medical Sciences, Kermanshah , Vaisi-Raygani, Asad Department of Clinical Biochemistry - Kermanshah University of Medical Sciences, Kermanshah
Abstract :
Hemoglobinopathies are the most common single gene disorders (monogenic disorders) in the world population. Due to specific position of Iran and the presence of multi-ethnic groups in the country, there are many varieties in the molecular genetics and clinical features of hemoglobinopathies in Iran. Hemoglobinopathies include structural variants, thalassemias, and hereditary persistence of fetal hemoglobin. In this review, we look at the common structural variants in various parts of the country along with their hematological and clinical characteristics. Also, we discuss about the burden of the thalassemias in the country, different types, complications, molecular defects and therapy.
Keywords :
Hemoglobinopathies , Thalassemia , Hb S , Hb D , Mutation
Journal title :
Astroparticle Physics
