Title of article
The Genotype Frequency of CYP2C19 Enzyme after Liver Transplantation
Author/Authors
Badiee, P Shiraz University of Medical Sciences, Shiraz , Hashemizadeh, Z Department of Organ Transplant Research Center - Shiraz University of Medical Sciences, Shiraz , Malek-Hosseini, S. A Department of Organ Transplant Research Center - Shiraz University of Medical Sciences, Shiraz , Geramizadeh, B Department of Pathology - Transplant Research Center - Shiraz University of Medical Sciences, Shiraz
Pages
6
From page
93
To page
98
Abstract
Background: Liver transplant recipients are treated with various drugs, the metabolism of which is dependent
on the cytochrome P450 polymorphic genotype.
Objective: To identify the polymorphic variety of CYP2C19 genotype in liver allograft before and after
transplantation.
Methods: The study was conducted on 88 liver recipients. The CYP2C19 genotypes in donors and recipients
were the same in 32 and different in 56 recipients. Extracted genomic DNA from the leukocytes and
liver graft tissues were analyzed by TaqMan SNP genotyping assay. The distributions of homozygote,
heterozygote, poor and ultra-rapid metabolizers’ genotypes were investigated in both groups.
Results: The distributions of CYP2C19 genotypes before transplantation in the blood and liver graft were
within the normal range. After transplantation, in patients with different CYP2C19 genotype in donors
and recipients, the genotypes of homozygote and ultra-rapid metabolizers were significantly decreased
(p=0.024); the heterozygotes and poor metabolizer genotypes were significantly increased (p=0.017).
Conclusion: The variety in CYP2C19 genotyping must be considered in patients with different genotypes
in donor and recipients to predict the dosage regimens, optimize the treatment and decrease toxicity.
Keywords
Cytochrome P450 , Poor metabolizer , CYP2C19 , Genotype , Ultra-rapid metabolizer , Liver transplantation
Journal title
Astroparticle Physics
Serial Year
2019
Record number
2485065
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