Title of article :
Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
Author/Authors :
Safaei, Akbar Department of Hematopathology - Molecular Pathology and Cytogenetics - Shiraz University of Medical Sciences - Shiraz, Iran , Monabati, Ahmad Department of Hematopathology - Molecular Pathology and Cytogenetics - Shiraz University of Medical Sciences - Shiraz, Iran , Mokhtari, Maral Department of Hematopathology - Molecular Pathology and Cytogenetics - Shiraz University of Medical Sciences - Shiraz, Iran , Solhjoo, Freidoon Department of Hematopathology - Molecular Pathology and Cytogenetics - Shiraz University of Medical Sciences - Shiraz, Iran , Montazer, Mehdi Department of Hematopathology - Molecular Pathology and Cytogenetics - Shiraz University of Medical Sciences - Shiraz, Iran
Abstract :
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare
hematodermic myeloid malignancy that is known to be derived from
plasmacytoid dendritic cells which are characterized by expression
of CD4, CD56, and more specific markers such as CD123. Here,
the authors present three cases of BPDCN diagnosed in the past
two years and address different available diagnostic modalities
such as morphology, immunohistochemistry, flow cytometry, and
cytogenetics. Overall, we believe that although BPDCN is a rare
diagnosis, it should not be left unchecked. Currently, available
immunophenotyping markers are of great help, but the main clue to
figure out the problem of BPDCN is clinicopathologic suspicion.
Keywords :
Iran , Dendritic cells , Leukemia
Journal title :
Astroparticle Physics
