Title of article :
Comparative Evaluation of Urinary Bladder Cancer Antigen and Urine Cytology in the Diagnosis of Bladder Cancer
Author/Authors :
Zargar Shoshtari, Mohammad Ali Department of Urology - Shaheed Hasheminejad Hospital - Iran University of Medical Sciences, Tehran , Soleimani, Mohammadjavad Department of Urology - Shaheed Hasheminejad Hospital - Iran University of Medical Sciences, Tehran , Moslemi, Mohammadkazem Department of Urology - Kamkar Hospital - Qom University of Medical Sciences, Qom
Pages :
4
From page :
137
To page :
140
Abstract :
Introduction: The diagnostic value of the urinary bladder cancer (UBC) antigen as a tumor marker is not clear yet. We designed this study to compare the accuracy of the UBC antigen and voided urine cytology in patients with bladder cancer. Materials and Methods: Fifty-four consecutive patients admitted for a diagnostic workup for bladder cancer were enrolled. Two voided urine samples were taken for urinalysis, both before performing cystoscopy. The samples were examined for urinary urine cytology and UBC antigen. Cystoscopy was done. Resection of pathologic lesion, if any, or random biopsies of multiple foci of the bladder was performed. The results of the diagnostic tests were compared with the pathology examination results. Results: Of 54 patients, 31 had histologically confirmed transitional cell carcinoma. Results were positive for UBC antigen in 28 and for urine cytology in 16 patients. Sensitivities and specificities were 74.2% and 78.3% for UBC antigen, 48.4% and 95.7% for urine cytology, and 87.1% and 73.9% for combined UBC antigen and cytology, respectively. Positive and negative likelihood ratios were 3.42 and 3.03 for UBC antigen, 11.3 and 1.85 for urine cytology, and 3.34 and 5.73 for combined UBC antigen and cytology, respectively. Conclusion: The UBC antigen test had acceptable sensitivity and specificity in our study. However, results of voided urine cytology are significantly more reliable. A combination of tumor markers may help diagnose new tumors and lower the requirements for cystoscopy during follow-up. Further studies are warranted to find a more accurate noninvasive test or a complex of tests comparable with cystoscopy for diagnosis of bladder cancer.
Keywords :
bladder cancer , diagnosis , tumor marker , urine cytology , urinary bladder cancer antigens
Journal title :
Astroparticle Physics
Serial Year :
2005
Record number :
2485684
Link To Document :
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