Author/Authors :
Tamaddoni, Ahmad Non-Communicable Pediatric Diseases Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, IR Iran , Alijanpour, Morteza Non-Communicable Pediatric Diseases Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, IR Iran , Mahmoodi, Hassan The Clinical Research Development Unit of Amirkola Children's Hospital - Babol University of Medical Sciences, Babol, IR Iran , Miladi, Beniamin Student Research Committee - Babol University of Medical Sciences, Babol, IR Iran , Bijani, Ali Social Determinants of Health Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, Iran , Assadollahi, Ehsan Student Research Committee - Babol University of Medical Sciences, Babol, IR Iran , Aghajanpour, Faeze Non-Communicable Pediatric Diseases Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, IR Iran
Abstract :
Background: Hyperglycemia is one of the most complications of corticosteroid and asparaginase during
induction phase of chemotherapy in children suffering from acute lymphoblastic leukemia (ALL).
This study was carried out to evaluate the incidence of hyperglycemia and associated risk factors during
chemotherapy induction phase at Amirkola Children's Hospital.
Materials and Methods: In this cross-sectional (retrospective) study, 150 children (mean age: 79.16±42.68
months) with ALL were evaluated (2000- 2011). Hyperglycemia was described as random blood glucose level
more than 200mg/dl in patients less than 2 years old. In patients older than 2 years, fasting blood glucose level
more than 110-125 mg/dl was considered as impaired glucose level and fasting blood glucose level more than
126 mg/dl was defined as diabetes mellitus. The data were analyzed using SPSS (version 18) and running chi
square test, pearson Ccorrelation, and logistic regression. P-values less than0.05 was considered statistically
significant.
Results: Out of 150 children with ALL, 21 (14%) of them had hyperglycemia, but none of them had diabetic
ketoacidosis. Hyperglycemia was significantly associated with gender (P=0.014) and age. (P=0.000) which was
more likely in patients older than 10 years. The incidence of hyperglycemia was also related to BMI (P=0.000).
Relapse rate for ALL was 14.7%, which was not significantly associated with hyperglycemia.
Conclusion: Hyperglycemia was common and transient during induction phase of chemotherapy and it was
correlated with age, sex, and weight.
