Title of article :
Evaluation of Anti-inflammatory and Membrane stabilizing property of Ethanol Extract of Cansjera rheedii J.Gmelin (Opiliaceae)
Author/Authors :
MOUTTAYA MOUNNISSAMY, VARADARASOU College of Pharmacy - Mother Theresa Institute of Health Sciences , KAVIMANI, SUBRAMANIAN College of Pharmacy - Mother Theresa Institute of Health Sciences , BALU, VAITHILINGAM College of Pharmacy - Mother Theresa Institute of Health Sciences , DARLIN QUINE, SABARIMUTHU School of Chemical and biotechnology - SASTRA Deemed University
Abstract :
Cansjera rheedii is widely used as a traditional medicine for the treatment and control of a variety of human inflammatory ailments by the fishermen of Auroville. In the present study, the anti-inflammatory and membrane stabilizing property of Ethanol Extract of Cansjera rheedii J. Gmelin (EECR) was evaluated in rat using the Human Red Blood Cells (HRBC) membrane stabilization method and carrageenin-induced acute paw edema model. The extract in concentration of 6-100µg/ml showed a dose-dependent inhibition of haemolysis of erythrocytes induced by hypotonic solution. Oral pre-treatment with EECR (250mg/kg) inhibited carrageenin-induced paw edema (41.93%) within 3 hrs. It is concluded that the extract possess anti-inflammatory as well as membrane stabilizing property.
Keywords :
Cansjera rheedii , Human red blood cell membrane stabilization , Carrageenin , Acute paw edema
Journal title :
Astroparticle Physics
