Title of article :
Safe chemotherapy and targeted therapy for treating locally advanced NPC in a G6PD-deficient patient: case report and literature review
Author/Authors :
Jiang, Y.M. Department of Radiation Oncology - Cancer Hospital of Guangxi Medical University, Nanning, People's Republic of China , Zhu, X.D. Department of Radiation Oncology - Cancer Hospital of Guangxi Medical University, Nanning, People's Republic of China
Abstract :
The article was first report a case of a 32-year-old female with NPC that is G6PD-deficient. The patient completed induction chemotherapy and concomitant chemoradiotherapy successfully. The patient experienced grade 1 neutropenia , grade 1 diarrhea, and grade 2 acne-like skin reactions during the three cycles of induction chemotherapy. Grade 1 neutropenia, grade 1 diarrhea, grade 2 oral mucositis and grade 1 skin reactions were observed during the concomitant chemoradiotherapy. No hemolytic events were observed. We conclude that it is safe for G6PD-deficient patients with NPC to received chemotherapy and targeted therapy.
Keywords :
nasopharyngeal carcinoma , G6PD deficiency , chemotherapy , cetuximab , radiotherapy
Journal title :
Astroparticle Physics
